Immunomodulatory effects of complex probiotics on the immuno-suppressed mice induced by cyclophosphamide.

ABSTRACT:

Introduction

Previous studies have reported the beneficial effects of Bifidobacterium animalis subsp. lactis XLTG11, Lacticaseibacillus casei Zhang, and Lactiplantibacillus plantarum P8, respectively. However, studies on the immunomodulatory enhancing effects of three complex probiotics have not been conducted. The aim of our study is to investigate the immunomodulatory effects of complex probiotics effect on the immunosuppressed mice induced by cyclophosphamide (CTX).

Methods

An immunocompromised mouse model was established by intraperitoneal injection of cyclophosphamide, which was gavage of different doses of complex probiotics and levamisole hydrochloride. The splenic and thymic indices, intestinal barrier, leukocyte and lymphocyte counts, per

SUBMITTER: Ma W 

PROVIDER: S-EPMC9911820 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature