Caulobacter and Novosphingobium in tumor tissues are associated with colorectal cancer outcomes.

ABSTRACT: Diversity and composition of the gut microbiome are associated with cancer patient outcomes including colorectal cancer (CRC). A growing number of evidence indicates that Fusobacterium nucleatum (Fn) in CRC tissue is associated with worse survival. However, few studies have further analyzed the differences in bacteria in tumor tissues of different patients depending on the survival time of CRC patients. Therefore, there is a need to further explore the bacterial differences in tumor tissues of patients with different prognoses and to identify key bacteria for analysis. Here, we sought to compare the differences in tumor microbiome between patients with long-term survival (LS) longer than 3 years or 4 and 5 years and patients with short-term survival (SS) in the present study cohort.

SUBMITTER: Zhou B 

PROVIDER: S-EPMC9911885 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature