Candidate loci shared among periodontal disease, diabetes and bone density.

ABSTRACT:

Introduction

While periodontal disease (PD) has been associated with type 2 diabetes (T2D) and osteoporosis, the underlying genetic mechanisms for these associations remain largely unknown. The aim of this study is to apply cross-trait genetic analyses to investigate the potentially shared biology among PD, T2D, and bone mineral density (BMD) by assessing pairwise genetic correlations and searching for shared polymorphisms.

Methods

We applied cross-trait genetic analyses leveraging genome-wide association study (GWAS) summary statistics for: Periodontitis/loose teeth from the UKBB/GLIDE consortium (PerioLT, N=506594), T2D from the DIAGRAM consortium (N_eff=228825), and BMD from the GEFOS consortium (N=426824). Among all three, pair-wise genetic correlations were es

SUBMITTER: Yu YH 

PROVIDER: S-EPMC9911896 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature