High-Throughput Next-Generation Sequencing of the Kidd Blood Group: Unexpected Antigen Expression Properties of Four Alleles and Detection of Novel Variants.

ABSTRACT:

Background

The blood supply for patients with foreign ethnic backgrounds can be challenging, as they often have blood group and HPA patterns that differ from the variants prevalent in the German population. In addition, hemoglobinopathies requiring regular blood transfusion may be more common in such populations. High-throughput genotyping tests can facilitate the identification of the most compatible blood products, thereby reducing the risk of transfusion reactions. The present study reports the results of a molecular study for the Kidd (JK) blood group. Allele frequencies and antigen prevalence data are presented for >8,000 individuals of various origins.

Material and methods

More than 8,000 blood donors were genotyped for 22 blood group systems and 5 HPA genes using an a

SUBMITTER: Vorholt SM 

PROVIDER: S-EPMC9911998 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature