Risk Factors and Outcomes of Stem Cell Mobilization Failure in Multiple Myeloma Patients.

ABSTRACT:

Introduction

Autologous hematopoietic stem cell transplantation (ASCT) is a well-established treatment for patients with multiple myeloma (MM), and adequate stem cell collection must be assured before ASCT. However, prediction of poor mobilizers (PMs) is still difficult despite several risk factors for mobilization failure having been identified.

Methods

We retrospectively analyzed MM patients at Taipei Veterans General Hospital in Taiwan who underwent stem cell collection between October 2006 and August 2020. A CD34⁺ cell collection of <1 × 10⁶ cells/kg was defined as a mobilization failure. The primary endpoint was mobilization failure. The secondary endpoint was overall survival (OS). Odds ratios (ORs) and 95% confidence intervals (CIs) for mobilizat

SUBMITTER: Hsu TL 

PROVIDER: S-EPMC9912005 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature