Vanadium exposure exacerbates allergic airway inflammation and remodeling through triggering reactive oxidative stress.

ABSTRACT:

Background

Metal components of environmental PM2.5 are associated with the exacerbation of allergic diseases like asthma. In our recent hospital-based population study, exposure to vanadium is shown to pose a significant risk for current asthma, but the causal relationship and its underlying molecular mechanisms remain unclear.

Objective

We sought to determine whether vanadium co-exposure can aggravate house dust mite (HDM)-induced allergic airway inflammation and remodeling, as well as investigate its related mechanisms.

Methods

Asthma mouse model was generated by using either vanadium pentoxide (V₂O₅) or HDM alone or in combination, in which the airway inflammation and remodeling was investigated. The effect of V₂O₅ co-exp

SUBMITTER: Tu W 

PROVIDER: S-EPMC9912158 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature