Allogeneic Hematopoietic Cell Transplantation vs Standard Consolidation Chemotherapy in Patients With Intermediate-Risk Acute Myeloid Leukemia: A Randomized Clinical Trial.

ABSTRACT:

Importance

The ideal postremission strategy in intermediate-risk acute myeloid leukemia (AML) in first complete remission (CR) has been a matter of debate.

Objective

To explore the optimal therapy for patients with intermediate-risk AML after first complete remission.

Design, settings, and participants

This investigator-initiated, open-label, 2-armed, phase 3 randomized clinical trial assessed patients at 16 hospitals in Germany from February 2, 2011, until July 1, 2018. Key eligibility criteria included cytogenetically defined intermediate-risk AML according to Medical Research Council classification, first CR or CR with incomplete blood cell count recovery after conventional induction therapy, age of 18 to 60 years, and availability of a human leukocyte antigen (HLA

SUBMITTER: Bornhauser M 

PROVIDER: S-EPMC9912165 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature