Inflammatory profile associated with insulin resistance in non-overweight versus overweight people living with HIV in Pune, Western India.

ABSTRACT:

Background

People living with HIV have greater diabetes (T2DM) than the general population despite lower prevalence of overweight/obesity. Both insulin resistance (IR), a T2DM precursor, and HIV are independently associated with chronic inflammation. Inflammation may be a pathophysiological link explaining IR in people living with HIV who are not overweight but is not well understood.

Aims

To study the association between inflammation and IR in non-overweight and overweight people living with HIV.

Methods

In a cohort of adult people living with HIV with undetectable viral load in Pune, India, we measured fasting insulin, glucose, and 9 inflammatory markers. IR was defined as HOMA-IR ≥2, and non-overweight as BMI ≤23 kg/m². We used modified Poisson regressio

SUBMITTER: Chebrolu P 

PROVIDER: S-EPMC9912190 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature