Redox Homeostasis in Well-differentiated Primary Human Nasal Epithelial Cells.

ABSTRACT: Oxidative stress (OS) in the airway epithelium is associated with inflammation, cell damage, and mitochondrial dysfunction that may initiate or worsen respiratory disease. Redox regulation maintains the equilibrium of pro-oxidant/antioxidant reactions but can be disturbed by environmental exposures. The mechanism(s) underlying the induction and impact of OS on airway epithelium and how these influences on respiratory disease is poorly understood. The aim of this study was to develop a stress response model in primary human nasal epithelial cells (NECs) grown at the air-liquid interface (ALI) into a well-differentiated epithelium and to use this model to investigate the mechanisms underlying OS. Hydrogen peroxide (H₂O₂) was used to induce acute OS and the responses wer

SUBMITTER: Yamamoto A 

PROVIDER: S-EPMC9912202 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature