Dataset Information

Estimating the cost consequence of the early use of botulinum toxin in post-stroke spasticity: Secondary analysis of a randomised controlled trial.

ABSTRACT:

Objective

To estimate the cost-consequence of treating spasticity early with botulinum toxin in the acute stroke unit.

Design

Secondary cost-consequence analysis, using data from a double-blind randomised-controlled trial.

Setting

Single-centre specialised stroke unit.

Subjects and interventions

Patients with Action Research Arm Test grasp-score of <2 and who developed spasticity within six weeks of a first stroke were randomised to receive injections of: 0.9% sodium-chloride solution (placebo) or onabotulinumtoxin-A (treatment).

Main measures

Resource use costs were calculated for the study. Mean contracture costs for each group were calculated. The Barthel Index and Action Research Arm Test were used to generate a cost per unit of improvement.

Results

There were no significant differences associated with early treatment use. The mean contracture cost for the treatment group was £817 and for the control group was £2298 (mean difference = -£1481.1(95% CI -£2893.5, -£68.7) (p = 0.04). The cost per unit of improvement for the Barthel Index was -£1240 indicating that the intervention costs less and is more effective. The cost per unit of improvement for the Action Research Arm Test was -£450 indicating that the intervention costs less and is more effective.

Conclusions

Treating spasticity early in stroke patients at risk of contractures with botulinum toxin leads to a significant reduction in contracture costs. The cost per improvement of Barthel and Action Research Arm Test indicates that the intervention costs less and is more effective.

Trial registration data

EudraCT(2010-021257-39) and ClinicalTrials.gov-Identifier:NCT01882556.

SUBMITTER: Lindsay C

PROVIDER: S-EPMC9912301 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Estimating the cost consequence of the early use of botulinum toxin in post-stroke spasticity: Secondary analysis of a randomised controlled trial.

Lindsay Cameron C Humphreys Ioan I Phillips Ceri C Pandyan Anand A

Clinical rehabilitation 20221103 3

<h4>Objective</h4>To estimate the cost-consequence of treating spasticity early with botulinum toxin in the acute stroke unit.<h4>Design</h4>Secondary cost-consequence analysis, using data from a double-blind randomised-controlled trial.<h4>Setting</h4>Single-centre specialised stroke unit.<h4>Subjects and interventions</h4>Patients with Action Research Arm Test grasp-score of <2 and who developed spasticity within six weeks of a first stroke were randomised to receive injections of: 0.9% sodium ...[more]

PMID: 36325678

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Dataset Information

Estimating the cost consequence of the early use of botulinum toxin in post-stroke spasticity: Secondary analysis of a randomised controlled trial.

Objective

Design

Setting

Subjects and interventions

Main measures

Results

Conclusions

Trial registration data

Publications

Estimating the cost consequence of the early use of botulinum toxin in post-stroke spasticity: Secondary analysis of a randomised controlled trial.

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