Effects of clozapine treatment on the improvement of substance use disorders other than nicotine in individuals with schizophrenia spectrum disorders: A systematic review and meta-analysis.

ABSTRACT:

Background

Antipsychotic medications are the mainstay of treatment for schizophrenia and are associated with a reduction in psychiatric hospitalization and overall mortality. Some evidence suggest that antipsychotic medications might have a varying effect on the improvement of comorbid substance use disorders (SUDs), with clozapine showing more favorable outcomes.

Aim

We systematically reviewed all available evidence on effects of clozapine on the improvement of SUDs other than nicotine.

Methods

Electronic searches of MEDLINE, Embase, PsycINFO, and CINHAL were conducted up to March 1, 2022. Studies of any methodological design involving two concepts: (1) clozapine and (2) SUD terms (excluding nicotine) were included. For SUD outcomes with three or more comparative stu

SUBMITTER: Rafizadeh R 

PROVIDER: S-EPMC9912304 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature