Dataset Information

Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.

ABSTRACT:

Background

Fatigue remains an important factor in major aviation accidents. Stimulants may counteract fatigue's adverse effects, with modafinil as a promising alternative to caffeine. However, the effect of a single dose of modafinil after a limited period of sleep deprivation remains unknown.

Aims

This study aims to determine the effect of 200 mg modafinil on vigilance during a limited period of sleep deprivation compared to 300 mg caffeine and placebo.

Methods

Thirty-two volunteers of the Royal Netherlands Air Force (RNLAF) were double-blindly administered modafinil, caffeine, and placebo on three non-consecutive trial days after being awake for median 17 h. Afterwards, subjects completed six series of the Vigilance and Tracking test (VigTrack), psychomotor vigilance task (PVT), and Stanford Sleepiness Scale (SSS), yielding six primary endpoints.

Results

This study revealed statistically significant effects of caffeine and modafinil compared with placebo on all endpoints, except for VigTrack mean tracking error. PVT results were less impaired 2 h after administration, followed by VigTrack parameters and SSS scores 2 h thereafter. Compared with caffeine, modafinil significantly improved PVT and SSS scores at 8 h after administration.

Conclusions

The present study demonstrates that 200 mg modafinil and 300 mg caffeine significantly decrease the effects of a limited period of sleep deprivation on vigilance compared with placebo. Although PVT parameters already improved 2 h after administration, the most notable effects occurred 2-4 h later. Modafinil seems to be effective longer than caffeine, which is consistent with its longer half-life.

SUBMITTER: Wingelaar-Jagt YQ

PROVIDER: S-EPMC9912306 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.

Wingelaar-Jagt Yara Q YQ Bottenheft Charelle C Riedel Wim J WJ Ramaekers Johannes G JG

Journal of psychopharmacology (Oxford, England) 20221214 2

<h4>Background</h4>Fatigue remains an important factor in major aviation accidents. Stimulants may counteract fatigue's adverse effects, with modafinil as a promising alternative to caffeine. However, the effect of a single dose of modafinil after a limited period of sleep deprivation remains unknown.<h4>Aims</h4>This study aims to determine the effect of 200 mg modafinil on vigilance during a limited period of sleep deprivation compared to 300 mg caffeine and placebo.<h4>Methods</h4>Thirty-two ...[more]

PMID: 36515156

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Dataset Information

Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.

Background

Aims

Methods

Results

Conclusions

Publications

Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.

Similar Datasets

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