Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.

ABSTRACT:

Background

Fatigue remains an important factor in major aviation accidents. Stimulants may counteract fatigue's adverse effects, with modafinil as a promising alternative to caffeine. However, the effect of a single dose of modafinil after a limited period of sleep deprivation remains unknown.

Aims

This study aims to determine the effect of 200 mg modafinil on vigilance during a limited period of sleep deprivation compared to 300 mg caffeine and placebo.

Methods

Thirty-two volunteers of the Royal Netherlands Air Force (RNLAF) were double-blindly administered modafinil, caffeine, and placebo on three non-consecutive trial days after being awake for median 17 h. Afterwards, subjects completed six series of the Vigilance and Tracking test (VigTrack), psychomotor vigilanc

SUBMITTER: Wingelaar-Jagt YQ 

PROVIDER: S-EPMC9912306 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature