APOE ε4 genotype, amyloid-β, and sex interact to predict tau in regions of high APOE mRNA expression.

ABSTRACT: The apolipoprotein E (APOE) ε4 allele is strongly linked with cerebral β-amyloidosis, but its relationship with tauopathy is less established. We investigated the relationship between APOE ε4 carrier status, regional amyloid-β (Aβ), magnetic resonance imaging (MRI) volumetrics, tau positron emission tomography (PET), APOE messenger RNA (mRNA) expression maps, and cerebrospinal fluid phosphorylated tau (CSF ptau₁₈₁). Three hundred fifty participants underwent imaging, and 270 had ptau₁₈₁. We used computational models to evaluate the main effect of APOE ε4 carrier status on regional neuroimaging values and then the interaction of ε4 status and global Aβ on regional tau PET and brain volumes as well as CSF ptau₁₈₁. Separately, we al

SUBMITTER: Dincer A 

PROVIDER: S-EPMC9912474 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature