Metallothionein expression in feline injection site fibrosarcomas.

ABSTRACT:

Background

Feline injection site fibrosarcoma is an aggressive and infiltrative tumour arising in the background of chronic inflammation. The aim of this study was to evaluate the expression of metallothionein (I-II) in feline injection site fibrosarcomas and to assess its possible relationships with Ki67 index, inflammation score and tumour grade. The study included 40 feline fibrosarcomas, located in the common injection sites (i.e., interscapular area, thigh, flank), constituting archival diagnostic specimens collected between 2019-2020. Tumours were graded histologically according to the newly proposed soft-tissue sarcoma grading system in cats. Immunohistochemistry was performed to evaluate the expression of Ki67 and metallothionein in tumour cells.

Results

The cytoplas

SUBMITTER: Mikiewicz M 

PROVIDER: S-EPMC9912506 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature