Pan-cancer analysis: predictive role of TAP1 in cancer prognosis and response to immunotherapy.

ABSTRACT:

Background

Transporter associated with antigen processing 1 (TAP1) is a molecule involved in processing and presentation of major histocompatibility complex class I restricted antigens, including tumor-associated antigens. TAP1 participates in tumor immunity, and is aberrantly expressed in multiple cancer types; METHODS: Transcriptome profiles were obtained from The Cancer Genome Atlas and Genotype-Tissue Expression databases. Genetic alterations, protein distribution, and interaction information for TAP1 were downloaded from cBioPortal, Human Protein Atlas and Compartmentalized Protein-Protein Interaction, respectively. Single-cell analyses of TAP1 across cancers were conducted via the Tumor Immune Single-cell Hub website. Gene set enrichment analysis was employed to investigate T

SUBMITTER: Tu Z 

PROVIDER: S-EPMC9912572 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature