Renal nerve stimulation identifies renal innervation and optimizes the strategy for renal denervation in canine.

ABSTRACT:

Background

Renal denervation (RDN) was still performed without any intra-procedural method for nerve mapping. Whether renal nerve stimulation (RNS) is an efficient way to identify renal autonomic innervation and optimize the strategy for RDN remain to be worthy for further exploration.

Methods

The characteristics of renal autonomic innervation at the sites with different blood pressure (BP) responses to RNS were explored. Then, dogs anatomically eligible for RDN were randomly assigned into elevated BP response ablation group, reduced BP response ablation group, and RNS-control group. The postoperative outcomes were measured at baseline and after 4 weeks follow-up.

Results

The proportion of afferent sensory nerve was higher at elevated BP response sites (ERS) than redu

SUBMITTER: Liu H 

PROVIDER: S-EPMC9912587 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature