Interferon and interferon-induced cytokines as markers of impending clinical progression in ANA⁺ individuals without a systemic autoimmune rheumatic disease diagnosis.

ABSTRACT:

Background

Elevated levels of interferons (IFNs) are a characteristic feature of systemic autoimmune rheumatic diseases (SARDs) and may be useful in predicting impending symptomatic progression in anti-nuclear antibody-positive (ANA⁺) individuals lacking a SARD diagnosis. Typically, these are measured by their effect on gene expression in the blood, which has limited their utility in clinical settings. Here, we assessed whether the measurement of serum IFN-α or selected IFN-induced cytokines accurately mirrors IFN-induced gene expression in ANA⁺ individuals and investigated their utility as biomarkers of clinical progression.

Methods

A total of 280 subjects were studied, including 50 ANA^- healthy controls, 160 ANA⁺ individuals with

SUBMITTER: Kim ST 

PROVIDER: S-EPMC9912609 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature