Protein content of blood-derived extracellular vesicles: An approach to the pathophysiology of cerebral hemorrhage.

ABSTRACT: Introduction: Extracellular vesicles (EVs) participate in cell-to-cell paracrine signaling and can be biomarkers of the pathophysiological processes underlying disease. In intracerebral hemorrhage, the study of the number and molecular content of circulating EVs may help elucidate the biological mechanisms involved in damage and repair, contributing valuable information to the identification of new therapeutic targets. Methods: The objective of this study was to describe the number and protein content of blood-derived EVs following an intracerebral hemorrhage (ICH). For this purpose, an experimental ICH was induced in the striatum of Sprague-Dawley rats and EVs were isolated and characterized from blood at baseline, 24 h and 28 days. The protein content in the EVs was analyze

SUBMITTER: Laso-Garcia F 

PROVIDER: S-EPMC9912619 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature