Association between diverticular disease and colorectal cancer: a bidirectional mendelian randomization study.

ABSTRACT:

Background

Diverticular disease has been inconsistently associated with colorectal cancer risk. We conducted a bidirectional Mendelian randomization study to assess this association.

Methods

Forty-three and seventy single-nucleotide polymorphisms associated with diverticular disease and colorectal cancer at the genome-wide significance level (p < 5 × 10^- 8) were selected as instrumental variables from large-scale genome-wide association studies of European descent, respectively. Summary-level data for colon cancer, rectum cancer, and colorectal cancer were obtained from genome-wide association analyses of the FinnGen consortium and the UK Biobank study. Summary-level data for diverticular disease was derived from a genome-wide association study conducted in the UK

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9912649 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature