"Two birds with one stone" strategy for the lung cancer therapy with bioinspired AIE aggregates.

ABSTRACT: Aggregation-induced emission luminogens (AIEgens) have emerged as novel phototherapeutic agents with high photostability and excellent performance to induce photodynamic and/or photothermal effects. In this study, a zwitterion-type NIR AIEgens C₄₁H₃₇N₂O₃S₂ (named BITT) with biomimetic modification was utilized for lung cancer therapy. The tumor-associated macrophage (TAM)-specific peptide (CRV) was engineered into the lung cancer cell-derived exosomes. The CRV-engineered exosome membranes (CRV-EM) were obtained to camouflage the BITT nanoparticles (CEB), which targeted both lung cancer cells and TAMs through homotypic targeting and TAM-specific peptide, respectively. The camouflage with CRV-EM ameliorated the surface function of BITT n

SUBMITTER: Lin Y 

PROVIDER: S-EPMC9912660 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature