The end-tidal alveolar dead space fraction for risk stratification during the first week of invasive mechanical ventilation: an observational cohort study.

ABSTRACT:

Background

The end-tidal alveolar dead space fraction (AVDSf = [PaCO₂-P_ETCO₂]/PaCO₂) is a metric used to estimate alveolar dead space. Higher AVDSf on the first day of mechanical ventilation is associated with mortality and fewer ventilator-free days. It is not clear if AVDSf is associated with length of ventilation in survivors, how AVDSf performs for risk stratification beyond the first day of ventilation, or whether AVDSf adds predictive value to oxygenation (oxygenation index [OI]) or severity of illness (Pediatric Risk of Mortality [PRISM III]) markers.

Methods

Retrospective single-center observational cohort study of children and young adults receiving invasive mechanical ventilation. In those with arterial or capillary blood

SUBMITTER: Bhalla AK 

PROVIDER: S-EPMC9912669 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature