Risks of second non-breast primaries following breast cancer in women: a systematic review and meta-analysis.

ABSTRACT:

Background

Second primary cancer incidence is rising among breast cancer survivors. We examined the risks of non-breast second primaries, in combination and at specific cancer sites, through a systematic review and meta-analysis.

Methods

We conducted a systematic search of PubMed, Embase, and Web of Science, seeking studies published by March 2022. We included studies that reported standardized incidence ratios (SIRs), with associated standard errors, assessing the combined risk of second non-breast primaries following breast cancer. We performed meta-analyses of combined second primary risks, stratifying by age, follow-up duration, and geographic region. We also assessed second primary risks at several specific sites, stratifying by age. The inverse variance method with Der

SUBMITTER: Allen I 

PROVIDER: S-EPMC9912682 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature