Extra-Basal Ganglia Brain Structures Are Related to Motor Reserve in Parkinson's Disease.

ABSTRACT:

Background

The "motor reserve" is an emerging concept based on the discrepancy between the severity of parkinsonism and dopaminergic degeneration; however, the related brain structures have not yet been elucidated.

Objective

We investigated brain structures relevant to the motor reserve in Parkinson's disease (PD) in this study.

Methods

Patients with drug-naïve, early PD were enrolled, who then underwent dopamine transporter (DAT) scan and diffusion tensor imaging (DTI). The severity of motor symptoms was evaluated with the Unified Parkinson's Disease Rating Scale score of bradykinesia and rigidity on the more affected side and dopaminergic degeneration of DAT uptake of the more affected putamen. Individual motor reserve estimate (MRE) was evaluated based on the discr

SUBMITTER: Youn J 

PROVIDER: S-EPMC9912725 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature