Diffusion-Weighted MRI in the Evaluation of Early-Stage Breast Cancer Treated with a Short Preoperative Radiotherapy: Preliminary Results.

ABSTRACT:

Objective

To assess tumor response with diffusion-weighted MRI (DW-MRI) after a short preoperative radiotherapy in early-stage breast cancer (BCa).

Materials and methods

This was a prospective, single-center pilot study. 3T-MRI were performed before and after radiotherapy. The longest diameter (LD) and the apparent diffusion coefficient (ADC) value of a region of interest (ROI) of the tumors were recorded. Histopathology and immunohistochemistry, including the Ki-67 index of the core biopsy and of the surgical specimen, were the reference standards.

Results

Nineteen patients with 22 early-stage BCa were included. The mean ROI ADC value was 1.093 ± 0.278 × 10^-3 mm²/s before radiotherapy and 1.490 ± 0.429 × 10^-3 mm²/s (p-value

SUBMITTER: Hottat N 

PROVIDER: S-EPMC9912849 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature