Effect of epithelial-specific MyD88 signaling pathway on airway inflammatory response to organic dust exposure.

ABSTRACT: The Toll-like receptor (TLR) adaptor protein MyD88 is integral to airway inflammatory response to microbial-enriched organic dust extract (ODE) exposures. ODE-induced airway neutrophil influx and release of pro-inflammatory cytokines was essentially abrogated in global MyD88-deficient mice, yet these mice demonstrate an increase in airway epithelial cell mucin expression. To further elucidate the role of MyD88-dependent responses specific to lung airway epithelial cells in response to ODE in vivo, the surfactant protein C protein (SPC) Cre⁺ embryologic expressing airway epithelial cells floxed for MyD88 to disrupt MyD88 signaling were utilized. The inducible club cell secretory protein (CCSP) Cre⁺, MyD88 floxed, were also developed. Using an established protoco

SUBMITTER: Johnson AN 

PROVIDER: S-EPMC9912912 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature