Bioinformatic prediction of the molecular links between Alzheimer's disease and diabetes mellitus.

ABSTRACT:

Background

Alzheimer's disease (AD) and type 2 diabetes mellitus (DM2) are chronic degenerative diseases with complex molecular processes that are potentially interconnected. The aim of this work was to predict the potential molecular links between AD and DM2 from different sources of biological information.

Materials and methods

In this work, data mining of nine databases (DisGeNET, Ensembl, OMIM, Protein Data Bank, The Human Protein Atlas, UniProt, Gene Expression Omnibus, Human Cell Atlas, and PubMed) was performed to identify gene and protein information that was shared in AD and DM2. Next, the information was mapped to human protein-protein interaction (PPI) networks based on experimental data using the STRING web platform. Then, gene ontology biological process (GOBP)

SUBMITTER: Castillo-Velazquez R 

PROVIDER: S-EPMC9912946 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature