Beneficial effects of prehospital use of statins in a large United States cohort of hospitalized coronavirus disease 2019 patients.

ABSTRACT:

Aims

This large cohort study aimed to assess the role of chronic statin use on COVID-19 disease severity.

Methods

An observational retrospective study from electronic medical records of hospitalized patients (n = 43 950) with COVID-19 between January and September 2020 in 185 hospitals in the United States. A total of 38 875 patients met inclusion criteria; 23 066 were included in the propensity-matched sampling with replacement cohort; 11 533 were prehospital statin users. The primary outcome was all-cause death; secondary outcomes were death from COVID-19 and serious complications. Mean, standard deviation, chi-square test, Student's t-test, linear regression, and binary and multinomial logistic regressions were used for statistical analysis.

Results

Among 38 875 pa

SUBMITTER: Crimi E 

PROVIDER: S-EPMC9912995 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature