Malaria patient spectrum representation in therapeutic clinical trials of uncomplicated malaria: a scoping review of the literature.

ABSTRACT:

Background

For the results of clinical trials to have external validity, the patients included in the study must be representative of the population presenting in the general clinical settings. A scoping literature review was performed to evaluate how the eligibility criteria used in anti-malarial efficacy and safety trials translate into patient selection.

Methods

A search of the WorldWide Antimalarial Resistance Network (WWARN) Clinical Trials Publication Library, MEDLINE, The Cochrane Library, and clinicaltrials.gov was conducted to identify trials investigating anti-malarial efficacy and safety, published between 14th April 2001 and 31st December 2017. An updated search using the WWARN Clinical Trial Publication Library was undertaken to identify eligible publications fr

SUBMITTER: Arena L 

PROVIDER: S-EPMC9913008 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature