Control of the post-infarct immune microenvironment through biotherapeutic and biomaterial-based approaches.

ABSTRACT: Ischemic heart failure (IHF) is a leading cause of morbidity and mortality worldwide, for which heart transplantation remains the only definitive treatment. IHF manifests from myocardial infarction (MI) that initiates tissue remodeling processes, mediated by mechanical changes in the tissue (loss of contractility, softening of the myocardium) that are interdependent with cellular mechanisms (cardiomyocyte death, inflammatory response). The early remodeling phase is characterized by robust inflammation that is necessary for tissue debridement and the initiation of repair processes. While later transition toward an immunoregenerative function is desirable, functional reorientation from an inflammatory to reparatory environment is often lacking, trapping the heart in a chronically inflamed st

SUBMITTER: Soni SS 

PROVIDER: S-EPMC9913034 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature