Inflammation and Prostate Cancer: Pathological Analysis from Pros-IT CNR 2.

ABSTRACT:

Background

Extensive research effort has been devoted to investigating the link between inflammation and PCa. However, this relationship remains unclear and controversial. The aim of our multi-center study was to investigate this association by histologically evaluating the distribution of PI and PCA in prostate biopsy cores from patients of eight referral centers in Italy.

Results

We evaluated 2220 cores from 197 patients; all the frustules were re-evaluated by dedicated pathologists retrospectively. Pathologists assigned IRANI scores and determined the positions of PIs; pathologists also re-evaluated the presence of PCa and relative ISUP grade. PCa was recorded in 749/2220 (33.7%). We divided this sample into a PCa PI group (634/749 cores [84.7%]) and a non-PCa + PI group

SUBMITTER: Sessa F 

PROVIDER: S-EPMC9913270 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature