Characterizing the Ablative Effects of Histotripsy for Osteosarcoma: In Vivo Study in Dogs.

ABSTRACT: Osteosarcoma (OS) is a malignant bone tumor treated by limb amputation or limb salvage surgeries and chemotherapy. Histotripsy is a non-thermal, non-invasive focused ultrasound therapy using controlled acoustic cavitation to mechanically disintegrate tissue. Recent ex vivo and in vivo pilot studies have demonstrated the ability of histotripsy for ablating OS but were limited in scope. This study expands on these initial findings to more fully characterize the effects of histotripsy for bone tumors, particularly in tumors with different compositions. A prototype 500 kHz histotripsy system was used to treat ten dogs with suspected OS at an intermediate treatment dose of 1000 pulses per location. One day after histotripsy, treated tumors were resected via limb amputation, and radiologic and h

SUBMITTER: Ruger LN 

PROVIDER: S-EPMC9913343 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature