Targeted Therapy of Interleukin-34 as a Promising Approach to Overcome Cancer Therapy Resistance.

ABSTRACT: Chemotherapy and immunotherapy have markedly improved the management of several malignancies. However, not all cancer patients respond primarily to such therapies, and others can become resistant during treatment. Thus, identification of the factors/mechanisms underlying cancer resistance to such treatments could help develop novel effective therapeutic compounds. Tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and regulatory T cells (Tregs) are major components of the suppressive tumor microenvironment and are critical drivers of immunosuppression, creating a tumor-promoting and drug-resistant niche. In this regard, therapeutic strategies to tackle immunosuppressive cells are an interesting option to increase anti-tumor immune responses and overcome the occu

SUBMITTER: Monteleone G 

PROVIDER: S-EPMC9913481 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature