Discovery of bioactive microbial gene products in inflammatory bowel disease.

ABSTRACT: Microbial communities and their associated bioactive compounds^1-3 are often disrupted in conditions such as the inflammatory bowel diseases (IBD)⁴. However, even in well-characterized environments (for example, the human gastrointestinal tract), more than one-third of microbial proteins are uncharacterized and often expected to be bioactive^5-7. Here we systematically identified more than 340,000 protein families as potentially bioactive with respect to gut inflammation during IBD, about half of which have not to our knowledge been functionally characterized previously on the basis of homology or experiment. To validate prioritized microbial proteins, we used a combination of metagenomics, metatranscriptomics and metaproteomics to provide evidence of bioacti

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9913614 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature