Non-Lethal Dose-Response Models Replace Lethal Bioassays for Predicting the Hazard of Para-Aminopropiophenone to Australian Wildlife.

ABSTRACT: Para-aminopropiophenone (PAPP) is a potent methaemoglobin (MetHb) forming agent used for the lethal control of exotic carnivores and mustelids. To assess the sensitivity of Australian wildlife to PAPP we developed an in vivo assay that did not use death as an endpoint. Sub-lethal dose-response data were modelled to predict PAPP doses required to achieve an endpoint set at 80% MetHb (MetHb₈₀). The comparative sensitivity of non-target mammals referenced to this endpoint was found to be highly variable, with southern brown bandicoots (Isoodon obesulus) the most sensitive species (MetHb₈₀ = 6.3 mg kg^-1) and bush rats (Rattus fuscipes) the most tolerant (MetHb₈₀ = 1035 mg kg^-1). Published LD₅₀ estimates were highly

SUBMITTER: Marks CA 

PROVIDER: S-EPMC9913665 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature