Intestinal Epithelial Cells Adapt to Chronic Inflammation through Partial Genetic Reprogramming.

ABSTRACT: Reactive oxygen species (ROS) are considered to be the main drivers of inflammatory bowel disease. We investigated whether this permanent insult compels intestinal stem cells to develop strategies to dampen the deleterious effects of ROS. As an adverse effect, this adaptation process may increase their tolerance to oncogenic insults and facilitate their neoplastic transformation. We submitted immortalized human colonic epithelial cells to either a mimic of chronic inflammation or to a chemical peroxide, analyzed how they adapted to stress, and addressed the biological relevance of these observations in databases. We demonstrated that cells adapt to chronic-inflammation-associated oxidative stress in vitro through a partial genetic reprogramming. Through a gene set enrichment analysis, we s

SUBMITTER: Collin G 

PROVIDER: S-EPMC9913703 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature