Tumor Treating Fields (TTFields) Therapy Concomitant with Taxanes for Cancer Treatment.

ABSTRACT: Non-small cell lung cancer, ovarian cancer, and pancreatic cancer all present with high morbidity and mortality. Systemic chemotherapies have historically been the cornerstone of standard of care (SOC) regimens for many cancers, but are associated with systemic toxicity. Multimodal treatment combinations can help improve patient outcomes; however, implementation is limited by additive toxicities and potential drug-drug interactions. As such, there is a high unmet need to develop additional therapies to enhance the efficacy of SOC treatments without increasing toxicity. Tumor Treating Fields (TTFields) are electric fields that exert physical forces to disrupt cellular processes critical for cancer cell viability and tumor progression. The therapy is locoregional and is delivered noninvasive

SUBMITTER: Vergote I 

PROVIDER: S-EPMC9913762 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature