IL-15 Prevents the Development of T-ALL from Aberrant Thymocytes with Impaired DNA Repair Functions and Increased NOTCH1 Activation.

ABSTRACT: We previously reported that NOD.Scid mice lacking interleukin-15 (IL-15), or IL-15 receptor alpha-chain, develop T-acute lymphoblastic leukemia (T-ALL). To understand the mechanisms by which IL-15 signaling controls T-ALL development, we studied the thymocyte developmental events in IL-15-deficient Scid mice from NOD and C57BL/6 genetic backgrounds. Both kinds of mice develop T-ALL characterized by circulating TCR-negative cells expressing CD4, CD8 or both. Analyses of thymocytes in NOD.Scid.Il15^-/- mice prior to T-ALL development revealed discernible changes within the CD4^-CD8^- double-negative (DN) thymocyte developmental stages and increased frequencies of CD4⁺CD8⁺ double-positive cells with a high proportion of

SUBMITTER: Nandi M 

PROVIDER: S-EPMC9913776 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature