¹¹C, ¹²C and ¹³C-Cyanation of Electron-Rich Arenes via Organic Photoredox Catalysis.

ABSTRACT: As a non-invasive imaging technology, positron emission tomography (PET) plays a crucial role in personalized medicine, including early diagnosis, patient screening, and treatment monitoring. The advancement of PET research depends on the discovery of new PET agents, which requires the development of simple and efficient radiolabeling methods in many cases. As bioisosteres for halogen and carbonyl moieties, nitriles are important functional groups in pharmaceutical and agrochemical compounds. Here, we disclose a mild organophotoredox-catalyzed method for efficient cyanation of a broad spectrum of electron-rich arenes, including abundant and readily available veratroles and pyrogallol trimethyl ethers. Notably, the transformations not only are compatible with various affordable ¹²

SUBMITTER: Wu X 

PROVIDER: S-EPMC9913897 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature