Feasibility of Dynamic Inhaled Gas MRI-Based Measurements Using Acceleration Combined with the Stretched Exponential Model.

ABSTRACT: Dynamic inhaled gas (³He/¹²⁹Xe/¹⁹F) MRI permits the acquisition of regional fractional-ventilation which is useful for detecting gas-trapping in lung-diseases such as lung fibrosis and COPD. Deninger's approach used for analyzing the wash-out data can be substituted with the stretched-exponential-model (SEM) because signal-intensity is attenuated as a function of wash-out-breath in ¹⁹F lung imaging. Thirteen normal-rats were studied using ³He/¹²⁹Xe and ¹⁹F MRI and the ventilation measurements were performed using two 3T clinical-scanners. Two Cartesian-sampling-schemes (Fast-Gradient-Recalled-Echo/X-Centric) were used to test the proposed method. The fully sampled dynamic wash-out images were retrospectively under

SUBMITTER: Sembhi R 

PROVIDER: S-EPMC9914115 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature