Pathways of TB Transmission in Children-A Systematic Review of Molecular Epidemiological Studies.

ABSTRACT: The widespread paradigm that younger children usually do not transmit M. tuberculosis complex (Mtbc) to their contacts has not yet been proven by genotypically confirmed transmissions. Therefore, we undertook a systematic review of molecular-epidemiological studies to investigate documented source and secondary TB (tuberculosis) cases among children. We searched the literature published before August 2022 using PubMed, Cochrane, and Google Scholar databases. PRISMA statement was used for systematic review. Of 312 records retrieved, 39 studies including children aged below 15 years offered epidemiological links between cluster members. In the 39 studies from 16 countries, 225 children were reported as cluster members of whom the overwhelming majority were infecte

SUBMITTER: Diel R 

PROVIDER: S-EPMC9914148 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature