Association between Body Mass Index and Diabetes Mellitus Are Mediated through Endogenous Serum Sex Hormones among Menopause Transition Women: A Longitudinal Cohort Study.

ABSTRACT:

Objective

To explore whether and to what extent endogenous sex hormones mediate the association between overweight and diabetes risk in menopausal transition women.

Methods

Premenopausal women were from the Study of Women's Health Across the Nation, with measurements of serum sex hormone including sex hormone binding globulin (SHBG), testosterone (T), estradiol (E2), follicle-stimulating hormone (FSH), and dehydroepiandrosterone sulfate (DHAS) in first postmenopausal follow-up. At the last postmenopausal follow-up, hyperglycemia status was confirmed. The partial least squares (PLS) regression method was used to extract hormonal signals associated with body mass index (BMI). Hyperglycemia was defined as individuals with prediabetes or diabetes; overweight was defined as BMI ≥

SUBMITTER: He L 

PROVIDER: S-EPMC9914507 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature