Oral Microbiota-One Habitat or Diverse Niches? A Pilot Study of Sampling and Identification of Oral Bacterial and Fungal Biota in Patients with Type I Diabetes Mellitus Treated with Insulin Pump.

ABSTRACT:

Objective

The oral microbiota is a very complex and dynamic microbial ecosystem. Alterations of its balance can result in oral and systemic diseases. We aimed to characterize the microbiota in particular niches of the oral cavity in adult type 1 diabetes patients treated with continuous infusion of insulin with insulin pump (IP). In addition, we aimed to determine optimal sites of oral microbiota sampling in studies of large research groups of patients with DM I.

Design

In this pilot study, we sampled the buccal and soft palate mucosa, tongue, palatal and buccal dental surfaces and gingival pockets of adult DM I patients treated with IP.

Results

In total, 23 patients were recruited. The oral microbiota was dominated by Streptococus and Neisseria, with a

SUBMITTER: Gregorczyk-Maga I 

PROVIDER: S-EPMC9914992 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature