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Aquaporin-5 Dynamic Regulation.

ABSTRACT: Aquaporin-5 (AQP5), belonging to the aquaporins (AQPs) family of transmembrane water channels, facilitates osmotically driven water flux across biological membranes and the movement of hydrogen peroxide and CO₂. Various mechanisms have been shown to dynamically regulate AQP5 expression, trafficking, and function. Besides fulfilling its primary water permeability function, AQP5 has been shown to regulate downstream effectors playing roles in various cellular processes. This review provides a comprehensive overview of the current knowledge of the upstream and downstream effectors of AQP5 to gain an in-depth understanding of the physiological and pathophysiological processes involving AQP5.

SUBMITTER: D'Agostino C

PROVIDER: S-EPMC9915196 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Aquaporin-5 Dynamic Regulation.

D'Agostino Claudia C Parisis Dorian D Chivasso Clara C Hajiabbas Maryam M Soyfoo Muhammad Shahnawaz MS Delporte Christine C

International journal of molecular sciences 20230118 3

Aquaporin-5 (AQP5), belonging to the aquaporins (AQPs) family of transmembrane water channels, facilitates osmotically driven water flux across biological membranes and the movement of hydrogen peroxide and CO<sub>2</sub>. Various mechanisms have been shown to dynamically regulate AQP5 expression, trafficking, and function. Besides fulfilling its primary water permeability function, AQP5 has been shown to regulate downstream effectors playing roles in various cellular processes. This review prov ...[more]

PMID: 36768212

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