Hypermetabolism in mice carrying a near complete human chromosome 21.

ABSTRACT: The consequences of aneuploidy have traditionally been studied in cell and animal models in which the extrachromosomal DNA is from the same species. Here, we explore a fundamental question concerning the impact of aneuploidy on systemic metabolism using a non-mosaic transchromosomic mouse model (TcMAC21) carrying a near complete human chromosome 21. Independent of diets and housing temperatures, TcMAC21 mice consume more calories, are hyperactive and hypermetabolic, remain consistently lean and profoundly insulin sensitive, and have a higher body temperature. The hypermetabolism and elevated thermogenesis are due to sarcolipin overexpression in the skeletal muscle, resulting in futile sarco(endo)plasmic reticulum Ca ²⁺ ATPase (SERCA) activity and energy dissipation. Mitochondria

SUBMITTER: Sarver DC 

PROVIDER: S-EPMC9915508 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature