B cell repertoire of children with atopic dermatitis exhibit altered IgE maturation associated with allergic food sensitization.

ABSTRACT: IgE B cells produce antibodies responsible for the inappropriate specificity seen in allergic disease. In this study, we sequence antibody gene repertoires from a large, well-characterized early life cohort at risk for developing food allergy. We found that food allergen sensitization was associated with lower IgE mutation frequencies that was abrogated in children living with a pet dog, suggesting potential molecular mechanisms underlying the hygiene hypothesis (i.e., protective effects of pet ownership and non-antiseptic environs reported for allergic disease). We also observed increased IgE diversity and increased isotype-switching to IgE, suggesting that B cell development is altered in those with food allergen sensitizations relative to those without. IgE diversity was even more extre

SUBMITTER: Gill KK 

PROVIDER: S-EPMC9915585 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature