Erasable Hippocampal Neural Signatures Predict Memory Discrimination.

ABSTRACT: Memories involving the hippocampus can take several days to consolidate, challenging efforts to uncover the neuronal signatures underlying this process. Using calcium imaging in freely moving mice, we tracked the hippocampal dynamics underlying memory formation across a ten-day contextual fear conditioning (CFC) task. Following learning, context-specific place field remapping correlated with memory performance. To causally test whether these hippocampal dynamics support memory consolidation, we induced amnesia in a group of mice by pharmacologically blocking protein synthesis immediately following learning. We found that halting protein synthesis following learning paradoxically accelerated cell turnover and also arrested learning-related remapping, paralleling the absence of remapping obs

SUBMITTER: Kinsky NR 

PROVIDER: S-EPMC9915633 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature