Aryl hydrocarbon receptor knockout accelerates PanIN formation and fibro-inflammation in a mutant Kras-driven pancreatic cancer model.

ABSTRACT:

Objectives

The pathogenesis of pancreas cancer (PDAC) remains poorly understood, hindering efforts to develop a more effective therapy for PDAC. Recent discoveries show the aryl hydrocarbon receptor (AHR) plays a crucial role in the pathogenesis of several cancers, and can be targeted for therapeutic effect. However, its involvement in PDAC remains unclear. Therefore, we evaluated the role of AHR in the development of PDAC in vivo.

Methods

We created a global AHR-null, mutant Kras-driven PDAC mouse model (A^-/-KC) and evaluated the changes in PDAC precursor lesion formation (Pan-IN 1, 2, and 3) and associated fibro-inflammation between KC and A^-/-KC at 5 months of age. We then examined the changes in the immune microenvironment followed by

SUBMITTER: Walcheck MT 

PROVIDER: S-EPMC9915668 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature