"Distinct inhibitory neurons differently shape neuronal codes for sound intensity in the auditory cortex".

ABSTRACT: Cortical circuits contain multiple types of inhibitory neurons which shape how information is processed within neuronal networks. Here, we asked whether somatostatin-expressing (SST) and vasoactive intestinal peptide-expressing (VIP) inhibitory neurons have distinct effects on population neuronal responses to noise bursts of varying intensities. We optogenetically stimulated SST or VIP neurons while simultaneously measuring the calcium responses of populations of hundreds of neurons in the auditory cortex of male and female awake, head-fixed mice to sounds. Upon SST neuronal activation, noise bursts representations became more discrete for different intensity levels, relying on cell identity rather than strength. By contrast, upon VIP neuronal activation, noise bursts of different intensit

SUBMITTER: Tobin M 

PROVIDER: S-EPMC9915672 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature