Functional Connectivity of the Cerebellar Vermis in Bipolar Disorder and Associations with Mood.

ABSTRACT:

Purpose

Studies of the neural underpinnings of bipolar type I disorder have focused on the emotional control network. However, there is also growing evidence for cerebellar involvement, including abnormal structure, function, and metabolism. Here, we sought to assess functional connectivity of the cerebellum with the cerebrum in bipolar disorder and to assess whether any effects might depend on mood.

Methods

This cross-sectional study enrolled 128 participants with bipolar type I disorder and 83 control comparison participants who completed a 3T MRI scan, which included anatomical imaging as well as resting state BOLD imaging. Functional connectivity of the cerebellar vermis to all other brain regions was assessed. Based on quality control metrics of the fMRI data, 109 parti

SUBMITTER: Saleem A 

PROVIDER: S-EPMC9915674 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature