Fecal virome transplantation is sufficient to alter fecal microbiota and drive lean and obese body phenotypes in mice.

ABSTRACT:

Background

The gastrointestinal microbiome plays a significant role in numerous host processes and has an especially large impact on modulating the host metabolism. Prior studies have shown that when mice receive fecal transplants from obese donors that were fed high-fat diets (HFD) (even when recipient mice are fed normal diets after transplantation), they develop obese phenotypes. These studies demonstrate the prominent role that the gut microbiota play in determining lean and obese phenotypes. While much of the credit has been given to gut bacteria, studies have not measured the impact of gut viruses on these phenotypes. To address this shortcoming, we gavaged mice with viromes isolated from donors fed HFD or normal chow. By characterizing the mice’s gut bacterial biota and we

SUBMITTER: Borin JM 

PROVIDER: S-EPMC9915734 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature